November 1, 2002AnesthesiologyOpen Access

Biphasic Effects of Isoflurane on the Cardiac Action Potential

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Why the study?

Does isoflurane modulate cardiac action potential duration and ionic currents in guinea pig ventricular myocytes?

Population

Single ventricular myocytes enzymatically isolated from guinea pig hearts

Comparison

Isoflurane at varying concentrations vs Baseline/control without isoflurane

Design

Preclinical

Authors

ASAkihiro SuzukiJichi Medical University KAKei AizawaTokai University SGSusanne GassmayrNational Postdoctoral Association

Discussion

Member takes

Implication

Isoflurane's biphasic APD effects in guinea pig myocytes warrant caution extrapolating to human anesthesia; leaves open confirmation in clinical electrophysiology.

Structured PICO

Does isoflurane modulate cardiac action potential duration and ionic currents in guinea pig ventricular myocytes?

Population

Single ventricular myocytes enzymatically isolated from guinea pig hearts

Intervention

Isoflurane at varying concentrations (0.6 mm, 1.0 mm, 1.8 mm)

Comparator

Baseline/control without isoflurane

Outcome

Cardiac action potential duration (APD50 and APD90) and modulation of ionic currents (I(Ca,L), I(Kdr), I(Kir))surrogate

Isoflurane exerts a concentration-dependent, biphasic effect on cardiac action potential duration in guinea pig ventricular myocytes, driven by differential inhibition of potassium and calcium currents.

Cite This Study

Suzuki et al. (2002) studied this question.

synapsesocial.com/papers/6a6f489eac440176ef27fc2d https://doi.org/10.1097/00000542-200211000-00026

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Implication

Isoflurane's biphasic APD effects in guinea pig myocytes warrant caution extrapolating to human anesthesia; leaves open confirmation in clinical electrophysiology.