July 1, 1996The Journal of PhysiologyOpen Access

Halothane and isoflurane preferentially depress a slowly inactivating component of Ca2+ channel current in guinea‐pig myocytes.

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Population

Isolated guinea-pig ventricular myocytes

Design

Preclinical

Authors

JPJoseph J. PancrazioThe University of Texas at Dallas

Discussion

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Implication

May underlie negative inotropy during volatile anesthesia; leaves open translation to human ventricular myocytes.

Structured PICO

Population

Isolated guinea-pig ventricular myocytes

Intervention

Halothane (0.9 mM in solution) and isoflurane (0.8 mM in solution)

Outcome

Peak whole-cell Ca2+ current (ICa) and channel inactivation propertiessurrogate

Halothane and isoflurane depress high-voltage-activated Ca2+ currents in guinea-pig ventricular myocytes primarily by reducing channel open probability and affecting the slow component of inactivation.

Cite This Study

Joseph J. Pancrazio (1996) studied this question.

synapsesocial.com/papers/6a6ff81853da1ffdb50799aa https://doi.org/10.1113/jphysiol.1996.sp021478

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Halothane and isoflurane preferentially depress a slowly inactivating component of Ca2+ channel current in guinea‐pig myocytes.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Halothane and isoflurane preferentially depress a slowly inactivating component of Ca2+ channel current in guinea‐pig myocytes.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider