April 1, 2000Anesthesia & Analgesia

Modulation of Cardiac Inward Rectifier K+ Current by Halothane and Isoflurane

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Population

Guinea pig ventricular myocytes

Design

Preclinical

Authors

ASAnna StadnickaJagiellonian University ZBZeljko J. BosnjakMedical College of Wisconsin JKJohn P. KampineElectrophysiology

Discussion

Member takes

Implication

May explain anesthetic dysrhythmias via IKir; hypothesis-generating for human translation.

Structured PICO

Population

Guinea pig ventricular myocytes

Intervention

Halothane and isoflurane

Outcome

Modulation of the inward rectifier K(+) current (IKir)surrogate

Volatile anesthetics like halothane and isoflurane modulate the myocardial inward rectifier potassium current, which may contribute to their dysrhythmic effects.

Cite This Study

Stadnicka et al. (2000) studied this question.

synapsesocial.com/papers/6a7272a4e5469ee92be26b16 https://doi.org/10.1097/00000539-200004000-00010

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Modulation of Cardiac Inward Rectifier K+ Current by Halothane and Isoflurane

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Modulation of Cardiac Inward Rectifier K+ Current by Halothane and Isoflurane

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider