February 1, 1989Pacing and Clinical Electrophysiology

The Electrophysiological Effects of Alpha‐Chloralose Anesthesia in the Intact Dog: (1) Alone and (2) in Combination with Verapamil

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Why the study?

Does alpha-chloralose anesthesia alter electrophysiological parameters and responses to verapamil in chronically instrumented dogs?

Population

13 chronically instrumented dogs

Comparison

Alpha-chloralose anesthesia alone and in… vs Baseline electrophysiological parameters in the…

Design

Preclinical

Authors

JSJanice B. SchwartzElectrophysiology JHJohn M. HerreOld Dominion University

Discussion

Member takes

Implication

Alpha-chloralose effects warrant consideration in interpreting canine EP data; leaves open whether similar confounds exist with other agents.

Structured PICO

Does alpha-chloralose anesthesia alter electrophysiological parameters and responses to verapamil in chronically instrumented dogs?

Population

13 chronically instrumented dogs

Intervention

Alpha-chloralose anesthesia (75 mg/kg of a 4% solution in polyethylene glycol) alone and in combination with verapamil

Comparator

Baseline electrophysiological parameters in the conscious state

Outcome

Electrophysiological parameters including P-R interval, A-H interval, AV nodal refractory periods, AV block cycle length, ventricular refractory period, and QTc intervalsurrogate

Alpha-chloralose anesthesia has significant electrophysiological effects in dogs, including delayed AV nodal conduction and prolonged refractoriness, which must be accounted for when interpreting experimental animal studies.

Cite This Study

Schwartz et al. (1989) studied this question.

synapsesocial.com/papers/6a708929f44fa9f079de334b https://doi.org/10.1111/j.1540-8159.1989.tb02661.x

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Implication

Alpha-chloralose effects warrant consideration in interpreting canine EP data; leaves open whether similar confounds exist with other agents.

The Electrophysiological Effects of Alpha‐Chloralose Anesthesia in the Intact Dog: (1) Alone and (2) in Combination with Verapamil

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Electrophysiological Effects of Alpha‐Chloralose Anesthesia in the Intact Dog: (1) Alone and (2) in Combination with Verapamil

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider