Why the study?
Does anesthesia (alpha-chloralose, Na pentobarbital, halothane) attenuate the cardiovascular response to carotid chemoreceptor stimulation in dogs compared to the conscious state?
Population
8 chronically instrumented dogs
Comparison
Anesthesia with alpha-chloralose, Na… vs Unanesthetized (conscious) state
Design
Preclinical
Authors
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Anesthetics blunt chemoreflexes in dogs; leaves open translation to human anesthesia and cardiovascular control.
Does anesthesia (alpha-chloralose, Na pentobarbital, halothane) attenuate the cardiovascular response to carotid chemoreceptor stimulation in dogs compared to the conscious state?
General anesthesia, including alpha-chloralose, severely interferes with carotid chemoreceptor control of the circulation in dogs.
Zimpfer et al. (1981) studied this question.
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