October 1, 1993AJP Regulatory Integrative and Comparative Physiology

Effects of anesthesia on cardiac and renal sympathetic nerve activities and plasma catecholamines

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Why the study?

Does pentobarbital or chloralose affect cardiac and renal sympathetic nerve activities and plasma catecholamines in conscious cats?

Population

Conscious cats

Comparison

Pentobarbital and Chloralose vs Baseline (pre-drug administration)

Design

Preclinical

Authors

KMKanji MatsukawaHiroshima University INI. NinomiyaHiroshima International University NNNaoki NishiuraKurashiki Central Hospital

Discussion

Member takes

Implication

Anesthetic choice may bias sympathetic recordings in feline models; leaves open translation to human cardiovascular research.

Structured PICO

Does pentobarbital or chloralose affect cardiac and renal sympathetic nerve activities and plasma catecholamines in conscious cats?

Population

Conscious cats

Intervention

Pentobarbital (25-30 mg/kg iv) and Chloralose (40-50 mg/kg iv)

Comparator

Baseline (pre-drug administration)

Outcome

Cardiac sympathetic nerve activity (CSNA), renal sympathetic nerve activity (RSNA), arterial pressure (AP), heart rate (HR), and plasma epinephrinesurrogate

Pentobarbital and chloralose differentially affect sympathetic outflows to the heart, kidney, and adrenal gland, attenuating tonic and baroreflex cardiac sympathetic outflow.

Cite This Study

Matsukawa et al. (1993) studied this question.

synapsesocial.com/papers/6a82a9c45bcab2ccdb8d654e https://doi.org/10.1152/ajpregu.1993.265.4.r792

View Full Paper

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Effects of anesthesia on cardiac and renal sympathetic nerve activities and plasma catecholamines

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of anesthesia on cardiac and renal sympathetic nerve activities and plasma catecholamines

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider