Why the study?
How do chloralose-urethane and sodium pentobarbitone anaesthesia affect the circulatory and autonomic responses to severe arterial hypoxia in rabbits?
Population
Normal rabbits, 'de-efferented' rabbits without functioning autonomic effectors, and atropinized rabbits
Comparison
Chloralose-urethane and sodium pentobarbitone… vs Unanaesthetized state (before anaesthesia)
Design
Preclinical
Authors
Loading...
Anaesthesia abolishes vagal hypoxia responses in rabbits; leaves open whether similar autonomic shifts occur in humans.
How do chloralose-urethane and sodium pentobarbitone anaesthesia affect the circulatory and autonomic responses to severe arterial hypoxia in rabbits?
Anaesthesia with chloralose-urethane or sodium pentobarbitone alters the autonomic response to hypoxia in rabbits, abolishing the hypoxia-induced increase in vagal efferent activity.
Körner et al. (1968) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: