September 1, 1982AnesthesiologyOpen Access

Halothane and the Carotid Sinus Reflex: Evidence for Multiple Sites of Action

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Why the study?

Does halothane anesthesia attenuate the carotid sinus baroreflex in dogs?

Population

Dogs (conscious and anesthetized)

Comparison

Halothane anesthesia vs Conscious dogs

Design

Preclinical

Authors

JSJ. L. SeagardMedical College of Wisconsin FHF. A. HoppMedical College of Wisconsin JDJudith H. DoneganUniversity of California, San Francisco

Discussion

Member takes

Implication

Halothane attenuates baroreflex via multiple sites in dogs; leaves open translation to humans or contemporary anesthetics.

Structured PICO

Does halothane anesthesia attenuate the carotid sinus baroreflex in dogs?

Population

Dogs (conscious and anesthetized)

Intervention

Halothane anesthesia (0.0%, 0.75%, and 1.5% halothane in 50% N2O and O2, plus 25 mg/kg thiopental)

Comparator

Conscious dogs

Outcome

Baroreflex effects on heart rate initiated by carotid sinus pressure changessurrogate

Halothane anesthesia attenuates the baroreceptor reflex in dogs through multiple mechanisms, including ganglionic blockade, depression of efferent responses, and sensitization of baroreceptor afferents.

Cite This Study

Seagard et al. (1982) studied this question.

synapsesocial.com/papers/6a7ca984e6f41aaf0bcf8293 https://doi.org/10.1097/00000542-198209000-00008

View Full Paper

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Halothane and the Carotid Sinus Reflex: Evidence for Multiple Sites of Action

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Halothane and the Carotid Sinus Reflex: Evidence for Multiple Sites of Action

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider