Key result
Halothane maintains constant pulmonary vascular and input resistance across baroreceptor stimulation regardless of nitrous oxide.
Why the study?
The effects of reflexly induced changes in sympathetic nerve activity on pulmonary hemodynamics during halothane and halothane-nitrous oxide anesthesia were not fully understood.
How do halothane and halothane-nitrous oxide anesthesia affect pulmonary hemodynamics during reflexly induced changes in sympathetic nerve activity in dogs?
Population
Vagotomized, open-chested dogs
Comparison
Halothane anesthesia at three end-tidal concentrations with and without 67% nitrous oxide
Design
Preclinical experimental study with isolated carotid sinus perfusion pressure changes
Authors
Loading...
Caution against extrapolating canine findings to patients; leaves open concentration-dependent pulmonary effects during baroreflexes in humans.
How do halothane and halothane-nitrous oxide anesthesia affect pulmonary hemodynamics during reflexly induced changes in sympathetic nerve activity in dogs?
In a canine model, pulmonary vascular resistance and input resistance remain constant during baroreceptor stimulation at ~0.9% halothane, but reflex changes become significant at higher or lower concentrations.
Bagshaw et al. (1981) studied Anesthesia. Halothane and halothane-nitrous oxide anesthesia with varying carotid sinus pressure was evaluated on Pulmonary vascular resistance and pulmonary input resistance. Pulmonary vascular resistance and pulmonary input resistance remained constant at end-tidal halothane concentrations of approximately 0.9% with or without nitrous oxide across a wide range of baroreceptor stimulation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: