Key result
Nitrous oxide increases mean arterial pressure and depresses carotid sinus reflex gain in halothane-anesthetized dogs.
Why the study?
The effects of 67% nitrous oxide on baroreceptor control of systemic haemodynamics in dogs under varying halothane concentrations were unclear.
Population
Dogs studied under different halothane concentrations
Comparison
67% nitrous oxide added to varying halothane levels (H1, H2, H3)
Design
Physiological study assessing baroreceptor function via brachiocephalic artery occlusion and isolated carotid sinus perfusion
Authors
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Should not alter human anesthetic practice; leaves open clinical relevance of nitrous oxide effects on baroreflex during halothane.
p-value: p=<0.001
Bagshaw et al. (1982) studied this question. Nitrous oxide was evaluated on Baroreceptor control of systemic haemodynamics (p=<0.001). In dogs, 67% nitrous oxide significantly increased mean arterial pressure at 0.9% halothane (P<0.001) and depressed the operating point gain of the carotid sinus reflex at other halothane levels (P<0.05).
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