Key result
Increasing halothane dose-dependently decreases the pressor response to brachiocephalic artery occlusion in dogs.
Population
Trained, chronically instrumented dogs
Comparison
Incremental end-tidal halothane levels during… vs Awake dogs undergoing brachiocephalic artery…
Design
Preclinical
Authors
Loading...
Halothane may impair baroreflex responses in dogs; extends animal observations but leaves open human relevance.
Effect estimate: r = -0.816
p-value: p=<0.001
Halothane produces a sensitive, dose-dependent depression of the baroreceptor reflex pressor response to carotid hypotension in dogs.
Bagshaw et al. (1981) studied Arterial baroreceptor function. Halothane vs. Awake controls was evaluated on Pressor response to brachiocephalic artery occlusion (r = -0.816, p=<0.001). Increasing halothane levels progressively decreased the pressor response to brachiocephalic artery occlusion in dogs in a dose-dependent manner (r = -0.816, P<0.001).
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: