Key result
Increasing end-tidal halothane reduces carotid sinus reflex gain and systemic arterial pressure reflex changes.
Why the study?
The dose dependency of carotid sinus reflex control of systemic haemodynamics during halothane anesthesia was not well characterized.
Population
Acute dog preparation with isolated perfused carotid sinuses
Comparison
Incremental end-tidal halothane levels of 0.66%, 0.88%, and 1.17%
Design
Preclinical experimental study
Authors
Loading...
May warrant halothane dose caution in baroreflex-sensitive states; leaves open human translation.
p-value: p=<0.01
Halothane causes a dose-dependent depression of the carotid sinus reflex control of systemic haemodynamics in dogs, with virtual ablation predicted at concentrations above 1.6%.
Bagshaw et al. (1981) studied this question. Halothane was evaluated on Carotid sinus reflex gain and range of reflex changes in systemic arterial pressure (p=<0.01). Increasing end-tidal halothane levels from 0.66% to 1.17% significantly decreased carotid sinus reflex gain and the range of reflex changes in systemic arterial pressure (P<0.01).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: