Why the study?
Early cardiovascular risk prediction in the general population is an important issue, and the prognostic value and genetic basis of T-wave morphology restitution (TMR) had not been evaluated in this setting.
Does T-wave morphology restitution (TMR) predict cardiovascular events in a middle-aged population?
Population
55 222 individuals undergoing exercise stress testing in UK Biobank
Comparison
Ventricular repolarization dynamics quantified by TMR during exercise and recovery
Design
Prospective cohort study and genome-wide association study
Follow-up
Median 7 years
Authors
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TMR may refine cardiovascular risk prediction in middle-aged adults; leaves open clinical integration and causal genetic roles pending validation.
Does T-wave morphology restitution (TMR) predict cardiovascular events in a middle-aged population?
T-wave morphology restitution (TMR) and its genetic risk score are significant independent predictors of cardiovascular events in a middle-aged population.
Ramírez et al. (2019) studied this question.
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