Why the study?
Does naftidrofuryl fumarate reduce serotonin-induced vasoconstriction in human mesenteric arteries in vitro?
Population
Human mesenteric arteries (in vitro organ bath experiments)
Comparison
Naftidrofuryl fumarate at 10 and 10 mol/l… vs Without NFT (control)
Design
Preclinical
Authors
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Naftidrofuryl may attenuate serotonin-mediated mesenteric vasoconstriction; hypothesis-generating in animal models and requires clinical validation before any practice consideration.
Does naftidrofuryl fumarate reduce serotonin-induced vasoconstriction in human mesenteric arteries in vitro?
Naftidrofuryl fumarate reduces serotonin-induced vasoconstriction in human mesenteric arteries in vitro, suggesting a potential role in preventing mesenteric vasospasm during colorectal surgery.
Fawcett et al. (1995) studied this question.
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