Why the study?
Which drugs should be used with caution in elderly patients to avoid intoxication and adverse drug events?
Which drugs should be used with caution in elderly patients to avoid intoxication and adverse drug events?
Careful management of pharmacotherapy in the elderly is necessary to avoid adverse drug events and maintain safety and quality of life.
May support cautious prescribing in elderly; leaves open prospective trials to confirm risks.
In recent decades, the world has undergone a demographic transformation with a rapid growth of the elderly population, resulting in an increased demand for funds to maintain their health and drug consumption. Pharmacokinetic and pharmacodynamic changes occurring in the elderly can interfere directly in the adverse effects of drugs and increase the risk of intoxication. In addition, there are external factors interfering with the pharmacotherapy of the elderly, such as inappropriate use and the lack of access to information. Many therapeutic classes of drugs should be used with caution or avoided in the elderly population, such as anti-inflammatory and some anti-hypertensive drugs, diuretics and digitalis. If not managed carefully, these medicines can affect the safety and quality of life in the elderly. Thus, the aim of this review was to identify drugs that should be used with caution in elderly patients in order to avoid intoxication and/or adverse drug events.
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Baldoni et al. (2010) studied this question.
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