Why the study?
Does female sex influence the prevalence of right ventricular dysfunction in patients with severe left ventricular systolic dysfunction?
Does female sex influence the prevalence of right ventricular dysfunction in patients with severe left ventricular systolic dysfunction?
Women with severe left ventricular systolic dysfunction have a significantly lower prevalence of right ventricular dysfunction compared to men, independent of hemodynamics and LVEF.
Women with severe LV systolic dysfunction had lower RVD prevalence; hypothesis-generating for sex differences, requiring prospective validation before clinical consideration.
AIM: To assess the influence of sex on right ventricular dysfunction (RVD) in patients with severe left ventricular systolic dysfunction. METHODS AND RESULTS: We studied 385 consecutive patients with left ventricular ejection fraction (LVEF) <0.35. All patients underwent invasive measurement of right ventricular and pulmonary artery pressures and evaluation of RVD by standard transthoracic echocardiography. Female patients (n=84, 21.8%) were significantly older than male patients (62.0+/-11.4 vs. 58.2+/-10.7 years), p=0.005. The prevalence of RVD was lower in women (26.5%) than in men (38.9%), p=0.03; both in patients with and without coronary artery disease (19.4% vs. 34.5% and 31.9% vs. 44.4%, respectively). Haemodynamic parameters and LVEF were similar in men and women. Low LVEF, pulmonary systolic pressure, degree of mitral regurgitation, male sex, and absence of significant coronary artery disease were independently correlated with RVD. CONCLUSION: Women with severe left ventricular systolic dysfunction have less RVD than men, despite similar haemodynamic parameters and LVEF.
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Martínez‐Sellés et al. (2006) studied this question.
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