Angiotensin II Receptor Blockade in Normotensive Subjects
Why the study?
Does a single dose of losartan, valsartan, or irbesartan provide greater and longer-lasting Ang II receptor blockade compared to placebo in normotensive subjects?
Population
12 normotensive subjects
Comparison
Single dose of losartan, valsartan, or… vs Placebo
Design
RCT, Randomized, 4-way crossover, Double-blind, placebo-controlled
Follow-up
30 hours
Authors
Discussion
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Member takes
Implication
Irbesartan delivers greater Ang II blockade than valsartan or losartan; supports differential ARB potency and guides initial agent selection.
Structured PICO
Does a single dose of losartan, valsartan, or irbesartan provide greater and longer-lasting Ang II receptor blockade compared to placebo in normotensive subjects?
P
Population
12 normotensive subjects
I
Intervention
Single dose of losartan (50 mg), valsartan (80 mg), or irbesartan (150 mg) administered at 1-week intervals
C
Comparator
Placebo
O
Outcome
Inhibition of the blood pressure response to exogenous Ang II at 4, 24, and 30 hours after drug intakesurrogate
A single starting dose of irbesartan provides greater and longer-lasting angiotensin II receptor blockade than valsartan or losartan in normotensive subjects.
Cite This Study
Mazzolai et al. (1999) studied this question.