The total synthesis of epothilone D with six-fold application in the intermediate stages of successive cyclopropanation — opening or cleavage of the three-membered ring was performed. These transformations underlie the new stereoselective method developed for coupling fragments C 7 –C 12 and C 13 –C 21 in the target molecule.
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Hurski et al. (2011) studied this question.
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