September 1, 1975
Effects of smoked marijuana in experimentally induced asthma.
Why the study?
Does smoked marijuana improve specific airway conductance and thoracic gas volume in subjects with experimentally induced asthma?
Population
8 subjects with clinically stable bronchial asthma undergoing experimentally induced acute bronchospasm
Comparison
500 mg of smoked marijuana or 0.25 ml of… vs 500 mg of smoked placebo marijuana or 0.25 ml of…
Design
Other
Follow-up
30 to 60 minutes
Authors
Discussion
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Member takes
Implication
May suggest acute bronchodilation in experimental asthma; leaves open any clinical role pending rigorous trials.
Structured PICO
Does smoked marijuana improve specific airway conductance and thoracic gas volume in subjects with experimentally induced asthma?
P
Population
8 subjects with clinically stable bronchial asthma undergoing experimentally induced acute bronchospasm (via methacholine or exercise)
I
Intervention
500 mg of smoked marijuana (2.0% delta9-tetrahydrocannabinol) or 0.25 ml of aerosolized isoproterenol (1,250 µg)
C
Comparator
500 mg of smoked placebo marijuana (0.0% delta9-tetrahydrocannabinol) or 0.25 ml of aerosolized saline
O
Outcome
Specific airway conductance and thoracic gas volumesurrogate
Smoked marijuana (2.0% THC) effectively reverses experimentally induced bronchospasm in subjects with stable bronchial asthma.
Cite This Study
Tashkin et al. (1975) studied this question.