July 11, 1974New England Journal of Medicine
Effect of Marihuana and Placebo-Marihuana Smoking on Angina Pectoris
Key result
Smoking marijuana reduces exercise time to angina by ~48% versus placebo.
- P<0.001
- n=10
Why the study?
The effect of smoking marihuana versus placebo marihuana on cardiovascular function and exercise-induced angina in patients with angina pectoris was evaluated.
Does smoking marihuana decrease exercise time until angina compared to placebo in patients with angina pectoris?
Population
10 patients with angina pectoris
Comparison
Smoking one marihuana cigarette vs smoking one placebo marihuana cigarette
Design
Randomized controlled trial
Authors
Discussion
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Implication
May warrant caution with marijuana in angina; leaves open chronic effects and need for modern confirmatory trials.
Study Design
Type
RCT (n=10)
Structured PICO
Does smoking marihuana decrease exercise time until angina compared to placebo in patients with angina pectoris?
P
Population
10 patients with angina pectoris evaluated for the acute effects of smoking marihuana versus placebo on exercise-induced angina.
I
Intervention
Smoking one marihuana cigarette
C
Comparator
Smoking one placebo marihuana cigarette
O
Outcome
Exercise time until angina, product of systolic blood pressure times heart rate, and venous carboxyhemoglobin levelsurrogate
Main Result
Absolute Event Rate: 48% vs 8.6%
p-value: p=<0.001
Smoking marijuana acutely decreases exercise tolerance in patients with angina pectoris by likely increasing myocardial oxygen demand and decreasing oxygen delivery.
Cite This Study
Aronow et al. (1974) conducted an RCT in Angina pectoris (n=10). Marihuana smoking vs. Placebo marihuana was evaluated on Decrease in exercise time until angina (p=<0.001). Smoking one marihuana cigarette significantly decreased exercise time until angina by 48% compared to an 8.6% decrease with placebo marihuana (p<0.001).