Key result
DHC-1 pretreatment protects against cardiorenal damage by reducing lipid peroxidation and boosting antioxidants in rats.
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Demonstrates protective antioxidant effects of herbal formulation DHC-1 against heart and kidney damage in rats, suggesting therapeutic potential against drug-induced organ toxicity.
DHC-1, an herbal formulation derived from the popular plants Bacopa monniera, Emblica officinalis, Glycyrrhiza glabra, Mangifera indica and Syzygium aromaticum was studied for its antioxidant activity. The protective effect of DHC-1 in isoproterenol-induced myocardial infarction and cisplatin-induced renal damage were studied. A significant reduction in the serum markers of heart and kidney damage and the extent of lipid peroxidation with a concomitant increase in the enzymatic (SOD and CAT) and non-enzymatic antioxidants (reduced glutathione) were observed in DHC-1 pretreated animals compared with the isoproterenol or cisplatin alone treated animals. Thus it can be concluded that DHC-1 possesses a protective effect against both damaged heart and kidneys in rats. This beneficial effect may be attributed, at least in part, to its antioxidant activity.
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Bafna et al. (2005) studied experimentally-induced cardiac and renal damage. DHC-1 vs. isoproterenol or cisplatin alone was evaluated on serum markers of heart and kidney damage, lipid peroxidation, and antioxidants. DHC-1 pretreatment protected against experimentally-induced cardiac and renal damage in rats by reducing serum markers and lipid peroxidation and increasing antioxidants.
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