Why the study?
Do antiarrhythmic drugs prolong the duration of recovery after electrical conversion of aconitine-induced atrial fibrillation in dogs?
Population
Open-chest dogs with aconitine-induced atrial fibrillation
Design
Preclinical
Authors
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May guide preclinical AF model testing; leaves open translation to human recurrence prevention.
Do antiarrhythmic drugs prolong the duration of recovery after electrical conversion of aconitine-induced atrial fibrillation in dogs?
In a canine model of aconitine-induced AF, drugs that effectively convert AF are not necessarily the most effective at preventing its recurrence after electrical conversion, with diphenylhydantoin showing the greatest prolongation of recovery time.
Byrne et al. (1970) studied this question.
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