September 27, 2005FEBS Letters

Rhinovirus‐stabilizing activity of artificial VLDL‐receptor variants defines a new mechanism for virus neutralization by soluble receptors

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Population

Minor group human rhinoviruses (HRV2)

Design

Preclinical

Authors

ANAndreas NicodemouUnited States Department of the Treasury MPM. PetschMedical University of Vienna TKTünde KonecsniMax Perutz Labs

Discussion

Member takes

Implication

Should not alter clinical practice; leaves open receptor-based neutralization strategies for further preclinical development.

Structured PICO

Population

Minor group human rhinoviruses (HRV2)

Intervention

Artificial concatemer of five copies of repeat 3 of the human very-low density lipoprotein receptor

Outcome

Protection against low-pH mediated uncoating and inhibition of penetration of an RNA-specific fluorescent dye into the intact virionsurrogate

Artificial VLDL-receptor variants neutralize rhinovirus by inhibiting viral breathing and capsid conformational changes, defining a new mechanism for virus neutralization.

Cite This Study

Nicodemou et al. (2005) studied this question.

synapsesocial.com/papers/6a70988a8031ec7bb1dc7351 https://doi.org/10.1016/j.febslet.2005.09.013

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Rhinovirus‐stabilizing activity of artificial VLDL‐receptor variants defines a new mechanism for virus neutralization by soluble receptors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Rhinovirus‐stabilizing activity of artificial VLDL‐receptor variants defines a new mechanism for virus neutralization by soluble receptors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider