Key result
A soluble very-low-density lipoprotein receptor (VLDLR) fragment shed from HeLa cells binds minor group rhinoviruses and inhibits viral infection in a concentration-dependent manner.
Population
HeLa cells and minor group human rhinoviruses
Design
Preclinical
Authors
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May inform soluble receptor-based antivirals; leaves open in vivo efficacy and clinical translation.
A soluble fragment of the human very-low-density lipoprotein receptor (VLDLR) can bind minor group human rhinoviruses and inhibit their infection of HeLa cells.
Marlovits et al. (1998) studied Human rhinovirus infection. Very-Low-Density Lipoprotein Receptor (VLDLR) fragment was evaluated on Inhibition of viral infection of HeLa cells. A soluble very-low-density lipoprotein receptor (VLDLR) fragment shed from HeLa cells binds minor group rhinoviruses and inhibits viral infection in a concentration-dependent manner.
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