Population
Major group human rhinovirus HRV89 and HEp-2 cells (ICAM-1-negative)
Design
Preclinical
Authors
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HRV89 receptor adaptation signals viral plasticity; leaves open relevance to human pathogenesis or entry-targeted therapies.
Human rhinovirus HRV89 can adapt to use alternative receptors for cell entry, demonstrating viral plasticity.
Reischl et al. (2001) studied this question.
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