Key result
HRV23 and HRV25 belong to the minor receptor group of human rhinoviruses, and the presence of a lysine in the VP1 HI loop is necessary but not sufficient for binding to the low-density lipoprotein receptor.
Population
In vitro cell lines and Human Rhinovirus serotypes
Design
Preclinical
Authors
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Hypothesis-generating for HRV receptor mapping; leaves open human validation of LDLR-binding requirements.
HRV23 and HRV25 belong to the minor receptor group of human rhinoviruses, and a conserved lysine in the VP1 HI loop is necessary but not sufficient for LDLR binding.
Vlasak et al. (2005) studied Human Rhinovirus (in vitro). Receptor binding assays was evaluated on Receptor specificity (LDLR vs ICAM-1). HRV23 and HRV25 belong to the minor receptor group of human rhinoviruses, and the presence of a lysine in the VP1 HI loop is necessary but not sufficient for binding to the low-density lipoprotein receptor.
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