Why the study?
Little is known about how an acute hypertensive stimulus affects cerebral blood flow regulation in an aged population.
Does aging reduce cerebral blood flow regulation following an acute hypertensive stimulus?
Does aging reduce cerebral blood flow regulation following an acute hypertensive stimulus?
Aging impairs cerebral blood flow regulation in response to acute blood pressure elevations, potentially contributing to cerebrovascular disease risk.
Answers are grounded in this paper and cite their sources.
Requires caution during acute hypertension in older adults; leaves open mechanisms and long-term cerebrovascular outcomes.
Reductions in cerebral blood flow and increases in flow pulsatility with aging are associated to cerebrovascular disease; however, little is known about how an acute hypertensive stimulus effects cerebral blood flow regulation in an aged population. Following the hypertensive stimulus, older adults elicit an attenuated increase in cerebral blood velocity and greater transmission of pulsatile velocity to the brain compared with young adults, demonstrating reduced cerebral blood flow regulation to elevated blood pressure responses with aging.
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Rosenberg et al. (2020) studied this question.
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