Key result
Advanced aging was associated with elevated pulsatility in BP and CBF, reduced low-frequency oscillations, and impaired baroreflex sensitivity and dynamic cerebral autoregulation at rest.
Population
136 healthy adults aged 21 to 80 years (60% women)
Design
Cross-sectional
Authors
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May signal heightened cerebrovascular vulnerability in aging; leaves open whether modulating pulsatility improves outcomes.
Cross-Sectional (n=136)
Advanced aging leads to increased hemodynamic stress on the cerebral circulation and diminished cardiovascular regulatory capability, particularly during postural changes.
Xing et al. (2017) conducted a cross-sectional in Healthy adults (n=136). Advanced aging vs. Young and middle-aged adults was evaluated on Age-related alterations in beat-to-beat oscillations in arterial blood pressure, heart rate, cerebral blood flow, cardiac baroreflex sensitivity, and dynamic cerebral autoregulation. Advanced aging was associated with elevated pulsatility in BP and CBF, reduced low-frequency oscillations, and impaired baroreflex sensitivity and dynamic cerebral autoregulation at rest.
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