January 10, 2007Journal of Biological ChemistryOpen Access

A Bipartite Sequence Motif Induces Translation Reinitiation in Feline Calicivirus RNA

View Full Paper

Ask AI

Bookmark

Population

Feline calicivirus RNA (transient expression studies)

Design

Preclinical

Authors

CLChristine LuttermannFriedrich-Loeffler-Institut GMGregor MeyersFriedrich-Loeffler-Institut

Discussion

Member takes

Implication

Hypothesis-generating for calicivirus antivirals; leaves open in vivo relevance and mammalian translation.

Structured PICO

Population

Feline calicivirus RNA (transient expression studies)

Intervention

Deletion mapping and mutation of sequence motifs in the 3'-terminal open reading frame 3 (ORF3) and preceding ORF2

Outcome

Efficiency of VP2 expression and translation reinitiation

Identifies a bipartite sequence motif in feline calicivirus RNA that induces translation reinitiation by potentially tethering the post-termination ribosome via 18 S rRNA hybridization.

Cite This Study

Luttermann et al. (2007) studied this question.

synapsesocial.com/papers/6a709896e5469ee92be14cb3 https://doi.org/10.1074/jbc.m608948200

View Full Paper

Ask AI

Bookmark

A Bipartite Sequence Motif Induces Translation Reinitiation in Feline Calicivirus RNA

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A Bipartite Sequence Motif Induces Translation Reinitiation in Feline Calicivirus RNA

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider