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September 1, 1977Journal of General Virology

Replication of Enterovirus 70 in Non-Primate Cell Cultures

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Population

Non-primate cell cultures including strain L, BHK21, RK13, RK17, PK15, IB-RS-2, ESK, MDBK, and BK1

Comparison

Infection with Enterovirus 70 strain J 670/71 at… vs Infection with LSc, 2ab strain of poliovirus…

Design

Preclinical

Authors

TYTakao YoshiiNational Institute of Infectious DiseasesKNKatsuro NatoriNational Institutes of HealthRKReisaku KonoAmerican Ceramic Society

Discussion

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Implication

EV70's broader non-primate cell tropism than PV1 warrants model caution; leaves open zoonotic or evolutionary implications.

Structured PICO

P
Population
Non-primate cell cultures including strain L (mouse), BHK21 (hamster), RK13 (rabbit), RK17 (rabbit), PK15 (porcine), IB-RS-2 (porcine), ESK (porcine), MDBK (bovine), and BK1 (primary bovine)
I
Intervention
Infection with Enterovirus 70 (EV70) strain J 670/71 at 33 degrees C
C
Comparator
Infection with LSc, 2ab strain of poliovirus type 1 (PV1)
O
Outcome
Viral replication and cytopathic effect (c.p.e.)surrogate

Enterovirus 70 has a wider host range in vitro than ordinary human enteroviruses, capable of replicating in various non-primate cell lines.

Cite This Study

Yoshii et al. (1977) studied this question.

synapsesocial.com/papers/6a7098fcfebe604dd7095e47https://doi.org/10.1099/0022-1317-36-3-377
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mammalian Cell-Virus Relationship. III. Poliovirus Production by Non-primate Cells Exposed to Poliovirus Ribonucleic Acid.1959 · 71 citations
  2. 2Propagation of Entero- and Other Viruses in Renal Cells Obtained from Non-Primate Hosts1960 · 13 citations
  3. 3Isolation of a virus responsible for an outbreak of acute haemorrhagic conjunctivitis in Morocco1974 · 19 citations
  4. 4SEROLOGIC CHARACTERIZATION AND SERO-EPIDEMIOLOGIC STUDIES ON ACUTE HEMORRHAGIC CONJUNCTIVITIS (AHC) VIRUS11975 · 34 citations
  5. 5Purified Rabbit Interferon: Attempts to Demonstrate Interferon-Specific 3 H-Protein1970 · 15 citations