Functional Groups at Concave Sites: Asymmetric Alkylation of Esters with Very High Stereoselectivity and Reversal of Configuration by Change of Solvent

This is the authors' abstract. We don't add key points for this paper.

An excellent asymmetric induction (enantiomeric excess >90%) is achieved in the α‐alkylation of esters of carboxylic acids and the alcohols (1) or (2) (see previous contribution). A drastic solvent effect (THF or THF‐HMPT 4:1) enables each of both enantiomers of a compound to be synthesized in high optical purity.