Chronic kidney disease increases cardiovascular unfavourable outcomes in outpatients with heart failure

83 outpatients with systolic chronic heart failure (ejection fraction ≤45%) stages B and C, mean age 62.7 ± 12 years, 56.6% female, from a single center in Brazil. Key inclusion: age >18 years, regular clinic attendance, optimized CHF treatment. Key exclusions: active infectious-contagious diseases, neoplasia, and reversible systolic CHF (valvular or coronary lesions with indication for correction).

Presence of chronic kidney disease (CKD), defined as estimated glomerular filtration rate <60 mL/min/1.73 m2

Absence of chronic kidney disease (estimated glomerular filtration rate ≥60 mL/min/1.73 m2)

Composite of cardiovascular death or hospitalization secondary to decompensated CHF during 12 months of follow-upcomposite