Why the study?
Does combination therapy with flecainide and metoprolol reduce symptomatic recurrences in patients with a recent episode of paroxysmal or persistent atrial fibrillation?
Population
173 patients with a recent episode of paroxysmal or persistent atrial fibrillation. Main exclusion criteria…
Comparison
Combination therapy with flecainide and metoprolol vs Flecainide only (n=72) or metoprolol only (n=21)
Design
RCT, randomized, open-blinded
Follow-up
1-year
Authors
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May reduce AF recurrences vs flecainide alone in persistent cases; leaves open need for larger RCTs before practice change.
Does combination therapy with flecainide and metoprolol reduce symptomatic recurrences in patients with a recent episode of paroxysmal or persistent atrial fibrillation?
Combination therapy with flecainide and metoprolol significantly reduces symptomatic recurrences and improves quality of life compared to flecainide alone in patients with persistent atrial fibrillation.
Capucci et al. (2016) studied this question.
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