Extracellular potassium ions may play a modulatory role in the action of some general anesthetic agents on human neuronal potassium currents.
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Caution against clinical extrapolation; leaves open potassium modulation of anesthetic effects on neuronal currents.
We demonstrate for the first time that the extracellular potassium concentration influences the inhibition of human neuronal delayed rectifier potassium currents by general anesthetics. This observation suggests a modulatory role for extracellular potassium ions in the action of some general anesthetic agents.
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Friederich et al. (1998) studied this question.
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