Why the study?
Does nadroparin during the first trimester improve pregnancy outcomes and prevent maternal complications in pregnant women with a mechanical heart valve compared to coumarin derivatives throughout pregnancy?
Population
31 pregnancies in 25 pregnant women with a mechanical heart valve prosthesis.
Comparison
Nadroparin between 6 and 12 weeks of gestation… vs Coumarin derivatives throughout pregnancy.
Design
Cohort
Follow-up
throughout pregnancy
Authors
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Nadroparin in first trimester was associated with better fetal outcomes in mechanical valve pregnancies; leaves open whether it should replace coumarins pending randomized data.
Does nadroparin during the first trimester improve pregnancy outcomes and prevent maternal complications in pregnant women with a mechanical heart valve compared to coumarin derivatives throughout pregnancy?
Nadroparin treatment during the first trimester in pregnant women with mechanical heart valves significantly improves fetal outcomes compared to coumarin derivatives throughout pregnancy, without increasing maternal thromboembolic risk.
Lee et al. (2007) studied this question.
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