Why the study?
Does gram-negative endotoxin stimulate procoagulant activity in human leukocytes in vitro?
Population
Human leukocytes from normal individuals (in vitro model)
Comparison
Incubation with gram-negative endotoxin in… vs Incubation in saline, or freshly collected…
Design
Preclinical
Authors
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In vitro finding only; leaves open endotoxin-stimulated leukocyte procoagulant activity in human sepsis coagulopathy.
Does gram-negative endotoxin stimulate procoagulant activity in human leukocytes in vitro?
Gram-negative endotoxin stimulates human leukocytes to develop tissue factor-like procoagulant activity in the presence of plasma or serum.
Lerner et al. (1971) studied this question.
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