Population
Rabbit or human leukocytes and platelets
Comparison
Addition of intact or disrupted platelets… vs Leukocytes incubated with endotoxin alone
Design
Preclinical
Authors
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May implicate platelets in sepsis-associated DIC; leaves open translation from this animal model to human disease.
Platelets contribute a membrane lipoprotein surface that enhances the procoagulant activity generated by leukocytes in the presence of endotoxin, which may play a role in disseminated intravascular coagulation during gram-negative sepsis.
Niemetz et al. (1974) studied this question.
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