Key result
Salmonella enteritidis lipopolysaccharide B endotoxin directly interacts with human platelet membranes, inducing a dose-dependent release of serotonin and adenine nucleotides.
Endotoxin directly interacts with human platelet membranes to induce selective release of serotonin and procoagulant activity, providing a potential mechanism for thrombocytopenia and hemostatic disorders in Gram-negative sepsis.
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May explain sepsis-related thrombocytopenia; hypothesis-generating from animal data and requires human validation.
Hawiger et al. (1977) studied Gram-negative sepsis. Salmonella enteritidis lipopolysaccharide B (endotoxin) vs. Zymosan and erythrocyte stroma was evaluated on Membrane changes manifested by release of [3H]serotonin and adenine nucleotides, and evolution of platelet factor 3 procoagulant activity. Salmonella enteritidis lipopolysaccharide B endotoxin directly interacts with human platelet membranes, inducing a dose-dependent release of serotonin and adenine nucleotides.