Key result
In vivo LPS challenge (2 ng/kg) in healthy volunteers rapidly decreased platelet count and elevated plasma CXCL4 levels within 10 minutes, despite no observable increase in surface CD62P.
Why the study?
Does LPS challenge induce early platelet activation in healthy volunteers?
Population
15 healthy volunteers
Comparison
Lipopolysaccharide 2 ng/kg in vivo challenge and… vs Baseline (before LPS challenge)
Follow-up
60 minutes
Authors
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May indicate early platelet sequestration in endotoxemia; hypothesis-generating for mechanisms in sepsis and requires clinical validation.
Does LPS challenge induce early platelet activation in healthy volunteers?
LPS rapidly activates platelets leading to alpha-granule release and endothelial adhesion, explaining the early drop in platelet count during endotoxemia.
Schrottmaier et al. (2016) studied Healthy volunteers (n=15). Lipopolysaccharide (LPS) vs. Baseline (before challenge) was evaluated on Platelet activation markers (GPIIb/IIIa, CD62P, CD40L, CXCL4) and platelet count. In vivo LPS challenge (2 ng/kg) in healthy volunteers rapidly decreased platelet count and elevated plasma CXCL4 levels within 10 minutes, despite no observable increase in surface CD62P.
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