Proposes a paradigm shift in understanding exercise fatigue, suggesting central nervous system regulation rather than peripheral muscle failure.
Challenges peripheral fatigue models; hypothesis-generating for central regulation, requiring prospective validation before practice impact.
It is a popular belief that exercise performance is limited by metabolic changes in the exercising muscles, so called peripheral fatigue. Exercise terminates when there is a catastrophic failure of homoeostasis in the exercising muscles. A revolutionary theory is presented that proposes that exercise performance is regulated by the central nervous system specifically to ensure that catastrophic physiological failure does not occur during normal exercise in humans.
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Noakes et al. (2004) studied this question.
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