Population
Knockin (RyR2/RyR2) mouse model of catecholaminergic polymorphic ventricular tachycardia and wild-type…
Comparison
Perfusion with Ca2+ and isoproterenol or… vs Wild-type littermates
Design
Preclinical
Authors
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His-Purkinje system may drive focal arrhythmias in CPVT; leaves open human relevance pending prospective validation.
The His-Purkinje system is an important source of focal arrhythmias in catecholaminergic polymorphic ventricular tachycardia, as demonstrated in a RyR2 knockin mouse model.
Cerrone et al. (2007) studied this question.
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