December 1, 1998HypertensionOpen Access

Biophysical Signals Underlying Myogenic Responses in Rat Interlobular Artery

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Population

Rat interlobular arteries from isolated perfused hydronephrotic kidneys, divided into proximal…

Design

Preclinical

Authors

TTTsuneo TakenakaInternational University of Health and Welfare HSHiromichi SuzukiYamagata University HOHirokazu OkadaUniversity of Tsukuba

Discussion

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Implication

Segment-specific myogenic mechanisms in rat renal arteries are hypothesis-generating; leaves open translation to human renovascular hypertension.

Structured PICO

Population

Rat interlobular arteries (ILAs) from isolated perfused hydronephrotic kidneys, divided into proximal (>60 microm), intermediate (40 to 60 microm), and distal (<40 microm) groups.

Intervention

Stepwise increase in perfusion pressure in the presence of pharmacological inhibitors (diltiazem, gadolinium, 2-nitro-4-carboxyphenyl-N, N-diphenyl-carbamate, staurosporine, thapsigargin)

Outcome

Myogenic responses (constriction/contraction)surrogate

The mechanisms underlying myogenic responses in rat interlobular arteries differ by segment, with distal segments relying on mechanosensitive cation channels and proximal segments on phospholipase C.

Cite This Study

Takenaka et al. (1998) studied this question.

synapsesocial.com/papers/6a70a0cafe4101aa97e03ff2 https://doi.org/10.1161/01.hyp.32.6.1060

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Implication

Segment-specific myogenic mechanisms in rat renal arteries are hypothesis-generating; leaves open translation to human renovascular hypertension.

Biophysical Signals Underlying Myogenic Responses in Rat Interlobular Artery

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Biophysical Signals Underlying Myogenic Responses in Rat Interlobular Artery

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider