Population
Rat heart and aorta, and rabbit vessels (mesenteric vein, portal vein of rats)
Design
Preclinical
Authors
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May indicate intracellular actions of calcium antagonists in animal tissue; leaves open relevance to human cardiovascular therapy.
Calcium antagonists may exert their effects by modulating the release and binding of calcium in intracellular pools rather than solely inhibiting transmembranous calcium influx.
Church et al. (1980) studied this question.
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