Key result
Calcium antagonists and reduced external calcium variably inhibit vascular smooth muscle adrenergic responses in vitro.
Why the study?
Calcium antagonists inhibit vascular smooth muscle activity variably depending on agent properties, tissue type, and activation method, but detailed comparative effects are unclear.
Population
Phasically active portal vein of rat and tonic aortae of rat and rabbit
Comparison
Reduced external calcium ion concentration and calcium antagonists felodipine, verapamil, and diltiazem versus control conditions
Design
In vitro experimental study on isolated vascular tissues
Authors
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Does not support clinical use of calcium antagonists for adrenergic vascular control; leaves open translation from animal tissue data.
Calcium antagonists inhibit adrenergic responses in vascular smooth muscle in a tissue- and concentration-dependent manner.
Ljung et al. (1987) studied this question. Calcium antagonists (felodipine, verapamil, diltiazem) and reduced external calcium vs. Control situation was evaluated on Noradrenaline (NA) responses. Calcium antagonists and reduced external calcium inhibited adrenergic responses of vascular smooth muscle in vitro in various ways depending on tissue type, means of activation, and concentrations.
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