September 18, 2008Blood Vessels

Differentiation of Calcium Activation Mechanisms in Vascular Smooth Muscle by Selective Suppression with Verapamil and D 600

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Population

Isolated portal vein and thoracic aorta of the guinea-pig

Design

Preclinical

Authors

KGK. GolenhofenPhilipps University of Marburg NHN HermsteinPhilipps University of Marburg

Discussion

Member takes

Implication

Distinguishes dual calcium pathways in animal vessels; leaves open human relevance and selective CCB targeting.

Structured PICO

Population

Isolated portal vein and thoracic aorta of the guinea-pig

Intervention

Verapamil and D 600 (methoxy-verapamil) up to 10^-5 mol/l

Outcome

Mechanical activity and dose-response curves to noradrenalinesurrogate

Demonstrates the existence of distinct calcium activation mechanisms in vascular smooth muscle, with differential sensitivity to calcium channel blockers like verapamil.

Limitations

Species differences
Differences in the specificity of various calcium antagonistic drugs

Cite This Study

Golenhofen et al. (2008) studied this question.

synapsesocial.com/papers/6a88f9ed4f37e970fb7b3ebc https://doi.org/10.1159/000158036

View Full Paper

Ask AI

Bookmark

Differentiation of Calcium Activation Mechanisms in Vascular Smooth Muscle by Selective Suppression with Verapamil and D 600

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Differentiation of Calcium Activation Mechanisms in Vascular Smooth Muscle by Selective Suppression with Verapamil and D 600

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider