Key result
In rat aortic rings, evoked EDRF release depends on mobilization of intracellular calcium rather than influx through verapamil-sensitive channels, while EDCF action is calcium-dependent.
Population
Rat aortic rings with and without endothelium
Design
Preclinical
Authors
Loading...
Does not support clinical translation of rat aortic calcium findings; leaves open human endothelial factor mechanisms.
This preclinical study elucidates the differential roles of intracellular and extracellular calcium in the release and action of endothelium-derived relaxing and constricting factors in rat aortas.
Olah et al. (2008) studied this question. Verapamil, propyl methylenedioxyindene (pr-MDI), and sodium nitroprusside vs. Rat aortic rings without endothelium was evaluated on Role of extracellular and intracellular calcium in EDRF and EDCF release and action. In rat aortic rings, evoked EDRF release depends on mobilization of intracellular calcium rather than influx through verapamil-sensitive channels, while EDCF action is calcium-dependent.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: