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January 1, 1985Clinical Science

Role of endothelium in the contractile response of rat aorta to α-adrenoceptor agonists

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Population

Rat isolated aorta preparations

Comparison

Endothelium removal and exposure to… vs Intact rat aorta preparations (with endothelium)

Design

Preclinical

Authors

TGThéophile GodfraindUCLouvainCECécile EglèmeUniversitätsklinikum des SaarlandesIOIyad Al OsachieUCLouvain

Discussion

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Overview

Endothelial modulation of alpha-agonist calcium responses shown in animals; leaves open human relevance and therapeutic translation.

Structured PICO

P
Population
Rat isolated aorta preparations
I
Intervention
Endothelium removal (denuded preparations) and exposure to alpha-adrenergic agonists (clonidine, noradrenaline) before and after calcium entry blockers (flunarizine, nifedipine)
C
Comparator
Intact rat aorta preparations (with endothelium)
O
Outcome
Contractile response to alpha-adrenergic agonistssurrogate

The study demonstrates that a factor released by endothelial cells regulates calcium entry and release in vascular smooth muscle in response to alpha-adrenoceptor agonists.

Cite This Study

Godfraind et al. (1985) studied this question.

synapsesocial.com/papers/6a8be9af7239707559bed99ahttps://doi.org/10.1042/cs068s065
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Influence of Endothelium on the Response to Calcium Agonists, Calcium, Potassium and Noradrenaline in Rat Aorta1988 · 16 citations
  2. 2Influence of the endothelium on Ca2+dependency of angiotensin II‐induced contractions of rat aortic rings1993 · 8 citations
  3. 3Quantitative changes in pharmacodynamic parameters of noradrenaline in different rat aorta preparation: influence of endogenous EDRF1998 · 6 citations
  4. 4Effect of Endothelin-1 on Calcium Channel Gating by Agonists in Vascular Smooth Muscle1989 · 56 citations
  5. 5Role of endothelium in the endothelin-1-mediated potentiation of the norepinephrine response in the aorta of hypertensive rats1997 · 22 citations