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December 1, 1989AJP Heart and Circulatory Physiology

The endothelium inhibits activation by calcium of vascular neurotransmission

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Population

Isolated rabbit carotid artery rings and segments

Comparison

Presence of endothelium and application of… vs Rings and segments without endothelium

Design

Preclinical

Authors

BTBelay TesfamariamCenter for Drug Evaluation and ResearchRWRobert M. WeisbrodBeth Israel Deaconess Medical CenterRCRichard A. CohenAchva Academic College

Discussion

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Overview

Endothelial calcium channel-dependent inhibition of adrenergic responses may modulate vascular tone; leaves open translation to human disease.

Structured PICO

P
Population
Isolated rabbit carotid artery rings and segments
I
Intervention
Presence of endothelium and application of voltage-dependent calcium channel activator BAY K 8644 (10(-6) M)
C
Comparator
Rings and segments without endothelium
O
Outcome
Vascular contractions and overflow of endogenous norepinephrinesurrogate

The endothelium inhibits adrenergic neurotransmission and vascular smooth muscle activation by extracellular calcium, a mechanism dependent on voltage-dependent calcium channels.

Cite This Study

Tesfamariam et al. (1989) studied this question.

synapsesocial.com/papers/6a8bd0d3c12eaf65c8b21cbbhttps://doi.org/10.1152/ajpheart.1989.257.6.h1871
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Influence of Endothelium on the Response to Calcium Agonists, Calcium, Potassium and Noradrenaline in Rat Aorta1988 · 16 citations
  2. 2Role of endothelium in the contractile response of rat aorta to α-adrenoceptor agonists1985 · 100 citations
  3. 3Endothelium inhibits responses of rabbit carotid artery to adrenergic nerve stimulation1987 · 90 citations
  4. 4Inhibition of endothelium-dependent vasorelaxation by extracellular K<sup>+</sup>: a novel controlling signal for vascular contractility2004 · 22 citations
  5. 5Calcium Channel Activation Does Not Increase Release of Endothelial-Derived Relaxant Factors (EDRF) in Rat Aorta Although Tonic Release of EDRF May Modulate Calcium Channel Activity in Smooth Muscle1986 · 53 citations