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November 1, 1991AJP Heart and Circulatory Physiology

Mechanisms of calcium relaxation of vascular smooth muscle

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Key result

Calcium-induced relaxation of vascular smooth muscle is partly mediated by endothelium-derived relaxing factors and partly by membrane stabilization of the smooth muscle cell.

Population

Intact and endothelium-denuded thoracic aortic rings of rats

Comparison

Various concentrations of calcium after… vs Endothelium-denuded rings, or intact rings…

Design

Preclinical

Authors

CWChun-Yi WuDBDavid F. Bohr

Discussion

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Overview

Animal data on calcium vasorelaxation mechanisms remain hypothesis-generating; human studies required before any clinical consideration.

Structured PICO

P
Population
Intact and endothelium-denuded thoracic aortic rings of rats
I
Intervention
Various concentrations of calcium (1.6 to 10.1 mM) after contraction induced by 30 mM KCl
C
Comparator
Endothelium-denuded rings, or intact rings treated with methylene blue (10(-5) M), A23187, or sodium nitroprusside
O
Outcome
Vascular relaxationsurrogate

Increased extracellular calcium causes vascular smooth muscle relaxation through both endothelium-derived relaxing factor release and direct membrane stabilization.

Cite This Study

Wu et al. (1991) studied this question. Calcium was evaluated on Relaxation of vascular smooth muscle after contraction induced by 30 mM KCl. Calcium-induced relaxation of vascular smooth muscle is partly mediated by endothelium-derived relaxing factors and partly by membrane stabilization of the smooth muscle cell.

synapsesocial.com/papers/6a932a671ef0caad2da18efehttps://doi.org/10.1152/ajpheart.1991.261.5.h1411
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Calcium- and endothelial-mediated vascular smooth muscle relaxation in rabbit aorta.1982 · 202 citations
  2. 2Influence of the endothelium on Ca2+dependency of angiotensin II‐induced contractions of rat aortic rings1993 · 8 citations
  3. 3Calcium Channel Activation Does Not Increase Release of Endothelial-Derived Relaxant Factors (EDRF) in Rat Aorta Although Tonic Release of EDRF May Modulate Calcium Channel Activity in Smooth Muscle1986 · 53 citations
  4. 4Mechanisms Underlying the Endothelium-Independent Relaxation Induced by Angiotensin II in Rat Aorta2005 · 37 citations
  5. 5Influence of Endothelium on the Response to Calcium Agonists, Calcium, Potassium and Noradrenaline in Rat Aorta1988 · 16 citations