May 1, 1992British Journal of PharmacologyOpen Access

Modulation of vascular tone by endothelin‐1: role of preload, endothelial integrity and concentration of endothelin‐1

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Population

Rat aortic rings

Comparison

Endothelin-1 exposure (10 to 10 M) under varying… vs Control conditions

Design

Preclinical

Authors

JMJ. L. MehtaUniversity of California, San Francisco DLDaniel LawsonCentral Michigan University BYBaichun YangChina Geological Survey

Discussion

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Implication

Supports dual ET-1 vasoactivity in rat models; hypothesis-generating for human endothelial function and endothelin therapies.

Structured PICO

Population

Rat aortic rings

Intervention

Endothelin-1 (ET-1) exposure (10(-11) to 10(-7) M) under varying preload conditions and with/without inhibitors (indomethacin, L-NMMA, oxyhaemoglobin) or endothelium removal

Comparator

Control conditions (quiescent rings, different preloads, or absence of inhibitors)

Outcome

Vascular tone (contraction or relaxation)surrogate

Endothelin-1 exhibits dual effects on vascular tone, acting as a constrictor in quiescent vessels but as an endothelium-dependent relaxant in precontracted vessels at low concentrations.

Cite This Study

Mehta et al. (1992) studied this question.

synapsesocial.com/papers/6a97467405b97d94ec9bb70e https://doi.org/10.1111/j.1476-5381.1992.tb14304.x

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Modulation of vascular tone by endothelin‐1: role of preload, endothelial integrity and concentration of endothelin‐1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Modulation of vascular tone by endothelin‐1: role of preload, endothelial integrity and concentration of endothelin‐1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider